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Hematology / Oncology

Cytogenetics

  • Chromosome analysis of stimulated cultures (peripheral blood)
  • Chromosome analysis of non-stimulated cultures (bone marrow and/or peripheral blood)
  • Chromosome breakage analysis - NOT Avalible in North America
  • Lymphocyte culture (bone marrow)

Molecular Cytogenetics

Detection by FISH

  • 11q23 deletion
  • 13q14.3 deletion
  • 20q12 deletion
  • 5q31 deletion
  • 5q33-34 deletion
  • 6q21 deletion
  • 7q31 deletion
  • 9q34 deletion
  • ALK rearrangements [del(2p); t(2;5)]
  • ATM (11q22.3) rearrangements
  • BCL-6 (3q27) rearrangements
  • CBFB rearrangements [(inv(16)/t(16;16)]
  • Chromosome 6 aneuploidy
  • Chromosome 9 aneuploidy
  • Chromosome 8 trisomy
  • Chromosome 12 trisomy
  • c-MYC (8q24) rearrangements
  • IGH (14q23) rearrangements
  • MALT1 (18q21) rearrangements
  • MLL (11q23) rearrangements
  • OncoFish for CLL (13q-, 11q-, 17p-, +12, IGH)
  • OncoFish for MDS (5q-, 7q-, 20q-)
  • OncoFish for MM [13q-, 17p-, t(4;14), t(11;14)]
  • p16 (9p21) deletion
  • PTEN (10q23) deletion
  • RARa (17q21) rearrangements
  • t(11;14) IGH/CCND1
  • t(11;18) API2/MALT1
  • t(12;21) ETV6/AML1
  • t(14;16) IGH/MAF
  • t(14;18) IGH/BCL2
  • t(14;18) IGH/MALT1
  • t(15;17) PML/RARa
  • t(4;14) IGH/FGFR3
  • t(8;14) MYC/IGH
  • t(8;21) AML1/ETO1
  • t(9;22) BCR/ABL

Molecular Diagnostics

  • AML1/ETO quantification
  • B cells (IGH) clonal rearrangement
  • BCR/ABL (p190) quantification
  • BCR/ABL (p210) quantification
  • Drug metabolism (CYP2D6, CYP2C9, CYP2C19, CYP3A4 and NAT2 genes)
  • IGK clonal rearrangement
  • JAK2 gene analysis (mutations on exon 12)
  • JAK2 gene analysis (V617F mutation)
  • JAK2 quantification
  • Li-Fraumeni Syndrome (TP53 gene)
  • MLP gene analysis (W515L/K mutations)
  • PML/RARa quantification
  • Resistance to Imatinib (c-KIT)
  • Resistance to Imatinib due to BCR/ABL mutations
  • Resistance to Methotrexate (SLC19A1 gene) under development
  • Resistance to Methotrexate (MTHFR gene)
  • t(11; 14) (IGH/BCL1) rearrangement
  • t(14; 18) (IGH/BCL2) rearrangement
  • TCRB clonal rearrangement
  • TCRG clonal rearrangement
  • TEL/AML1 quantification
  • TP53 (sequence analysis)
  • WT1 quantification
  • Xenobiotics metabolism (GSTM1, GSTT1 and NAT2 genes)